| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Mouse Siglec E-Fc Chimera (carrier-free) |
|---|
| Description | Siglecs (sialic acid binding Ig-like lectins) are type I membrane proteins with an extracellular region containing a sialic acid binding V-set Ig-like domain at the N-terminus, followed by varying numbers of C2-set Ig domains. The cytoplasmic tails of all siglecs have one or more tyrosines within potential signalling motifs. Siglecs are widely expressed on hematopoietic cells, often in a cell-type-specific manner. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Studies suggest that siglecs may participate in cell-cell interactions or act as receptors for the entry of viral or bacterial pathogens. In addition, the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic domain indicates that these molecules may play a role in the suppression of immunoreceptor signaling. The siglecs can be classified into two subgroups, with Siglec-1, -2, and -4 as one group and a Siglec-3/CD33-related subgroup (Siglec-3, and -5 through -13) as the second. Siglec E is a mouse CD33-related siglec that selectively regulates early recruitment of neutrophils to the lung in acute lung inflammation induced by lipopolysaccharide. Siglec E-deficient mice exhibit exaggerated neutrophil recruitment that is reversible by using a blockade of the β2 integrin, CD11b. In addition, sialidase treatment of fibrinogen reverses the suppressive effect of Siglec E on CD11b signaling, suggesting that sialic acid recognition by Siglec E is required for its inhibitory function. These findings indicate that Siglec E is an important negative regulator of neutrophil recruitment to the lung and β2 integrin-dependent signaling. |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Siglec E, CD170, Sialic acid-binding Ig-like lectin E, Siglec 9, Siglecl1 |
|---|
| Gene, Accession, CAS # | Gene ID: 83382 |
|---|
| Catalog # | 551506 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Mouse Siglec E-Fc Chimera (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|