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| Product Name | Recombinant Mouse TNFRII (CD120b) (carrier-free) |
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| Description | The biological effects of TNF are mediated by two cell surface TNF receptors: TNFRI (TNF-RI) and TNFRII (also known as TNFRII (CD120B) and TNF-RII). TNFRI and TNFRII are structurally related, but functionally distinct. Also, TNFRI is widely expressed on most cells, whereas TNFRII is more restricted and is primarily expressed in hematopoietic cells and cells of the immune system. The function of TNFRII is less understood and has fewer biological effects than TNFRI. Unlike TNFRI, TNFRII does not have a death domain and will induce NF-κB activation through a different pathway. It is generally accepted that TNFRI induces both apoptosis and survival pathways, while TNFRII induces only survival pathway. Only membrane-bound TNF can active TNFRII effectively. Soluble TNF can bind TNFRII, but can not induce TNFRII signaling. Upon binding of TNF, TNFRII will form a trimer and will recruit TRAF2, therefore leading to the activation of NF-κB. In T cells, TNFRII costimulation provides survival signals during the differentiation program triggered by TCR-mediated stimulation and also during clonal expansion in response to intracellular bacterial pathogens. Both TNFRI and TNFRII can be released from cell surface by ectodomain shedding. The resulting soluble TNFRI and TNF-RII can bind TNF with high affinity and modulate TNF effects. An in vitro study showed that both TNFRI and TNFRII are constitutively released from monocytes. LPS stimulation can further increase soluble TNFRII release. It has been reported that TNFRII polymorphism is associated with some lymphomas, solid tumors, and autoimmune diseases. The plasma level of soluble TNFRII is increased in obese people and is related to insulin resistance. In addition, recombinant Fc-tagged soluble TNFRII has been used to treat rheumatoid arthritis. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | p75TNFR, CD120b, TNF RII, tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), TNFBR, TNFR80, TNF receptor beta chain, p75 TNFR, p80 TNF-alpha receptor, tumor necrosis factor receptor 2 |
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| Gene, Accession, CAS # | Gene ID: 21938 |
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| Catalog # | 758904 |
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| Order / More Info | Recombinant Mouse TNFRII (CD120b) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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