| 产品详情 |
| Edit |   |
|---|
| Product Name | Sunitinib (malate) |
|---|
| Description | A multi-kinase inhibitor; inhibits FLK1 (Ki = 9 nM), PDGFRβ (Ki = 8 nM), and FLT3; at least 10-fold selective for FLK1 and PDGFRβ over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl, and Src; inhibits VEGF-dependent FLK1 and PDGF-dependent PDGFRβ phosphorylation (IC50s = 10 and 10 nM, respectively); inhibits phosphorylation of FLT3 and FLT3-ITD (IC50s = 250 and 50 nM, respectively); decreases VEGF- and FGF-induced proliferation of HUVECs; IC50s = 30 and 700 nM, respectively); reduces tumor growth in a variety of mouse xenograft models at 20-80 mg/kg per day |
|---|
| Size | 50 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | SU11248 |
|---|
| Gene, Accession, CAS # | CAS: 341031-54-7 |
|---|
| Catalog # | 13159-50 |
|---|
| Price | |
|---|
| Order / More Info | Sunitinib (malate) from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|