| 产品详情 |
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| Product Name | Recombinant Human PLA2G7 (carrier-free) |
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| Description | Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a phospholipid messenger synthesized by a variety of cells involved in host defense, such as endothelial cells, platelets, neutrophils, monocytes, and macrophages. High levels of PAF are responsible for a variety of human diseases such as inflammation, asthma, necrotizing enterocolitis, and sepsis. Phospholipase A2 Group VII (PLA2G7), also known as platelet- activating factor acetylhydrolase (PAFAH) or lipoprotein binding phospholipase A2 (Lp-PLA2), is an enzyme that hydrolyzed the acetyl group at the sn-2 position of the glycerol backbone from PAF to inactivate PAF. It has poor specificity toward Sn-2 long chain fatty acid. It also can hydrolyze oxidized phospholipids such as those within oxidized LDL, generating proinflammatory moieties lysophosphatidylcholine and oxidized fatty acids. Considering the proinflamatory properties of PAF and oxidized phospholipids, PLA2G7 plays a role in protecting cells from uncontrolled oxidative/inflammatory damage. A person with PLA2G7 deficiency is at an increased risk to develop a range of inflammatory disorders. PLA2G7 is produced primarily by macrophages and lymphocytes. The expression of plasma PLA2G7 is transcriptionally modulated by the mediators of inflammation, for example the promoter of the PLA2G7 gene is positively regulated by PAF and negatively regulated by interferon γ and lipopolysaccharide. The majority of the plasma PLA2G7 (approximately two-thirds) is bound to LDLs as it circulates in plasma, while the remaining plasma enzyme associates with HDLs and other lipoproteins. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Lipoprotein binding phospholipase A2 (Lp-PLA2), LDL-PLA2, Phospholipase A2 Group VII, platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) acetyl hydrolase (PAFAH), PAF-AH |
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| Gene, Accession, CAS # | Gene ID: 7941 |
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| Catalog # | 762906 |
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| Order / More Info | Recombinant Human PLA2G7 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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