| 产品详情 |
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| Product Name | Recombinant Escherichia coli Alpha-ketoglutarate-dependent dioxygenase AlkB (alkB) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 44.1kDa. Full Length: 1-216aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Escherichia coli (strain K12). Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Alkylated DNA repair protein AlkB; DNA oxidative demethylase AlkB |
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| Gene, Accession, CAS # | alkB, UniProt: P05050 |
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| Catalog # | RPC22689 |
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| Order / More Info | Recombinant Escherichia coli Alpha-ketoglutarate-dependent dioxygenase AlkB (alkB) from BIOMATIK |
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| Product Specific References | n/a |
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