产品名称 Recombinant Human Interferon regulatory factor 7 (IRF7) from BIOMATIK
产品货号 RPC26069
产品价格 现货询价,电话:010-67529703
产品规格 100ug
产品品牌 BIOMATIK
产品概述
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Product NameRecombinant Human Interferon regulatory factor 7 (IRF7)
DescriptionPurity > 85% as determined by SDS-PAGE. MW: 54.3kDa. Full Length: 1-503aa. tag-Free. Homo sapiens (Human). Key transcriptional regulator of type I interferon-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes and IFN-stimulated genes by binding to an interferon-stimulated response element in their promoters. Can efficiently activate both the IFN-beta and the IFN-alpha genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter of EBV nuclear antigen 1 a and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
Size100ug
Concentrationn/a
ApplicationsRUO
Other NamesIRF-7
Gene, Accession, CAS #IRF7, UniProt: Q92985
Catalog #RPC26069
Price
Order / More InfoRecombinant Human Interferon regulatory factor 7 (IRF7) from BIOMATIK
Product Specific Referencesn/a
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