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| Product Name | Recombinant Human Interleukin-36 alpha (IL36A) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 44.7kDa. Full Length: 1-158aa. N-terminal GST-tagged. Homo sapiens (Human). Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | FIL1 epsilon; Interleukin-1 epsilon |
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| Gene, Accession, CAS # | IL36A, UniProt: Q9UHA7 |
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| Catalog # | RPC23710 |
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| Order / More Info | Recombinant Human Interleukin-36 alpha (IL36A) from BIOMATIK |
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| Product Specific References | n/a |
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