产品名称 Recombinant Human Interleukin-1 alpha protein (IL1A) (Active) from BIOMATIK
产品货号 RPC26800
产品价格 现货询价,电话:010-67529703
产品规格 n/a
产品品牌 BIOMATIK
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Product NameRecombinant Human Interleukin-1 alpha protein (IL1A) (Active)
DescriptionPurity > 95% as determined by SDS-PAGE. MW: 7.67kDa. Partial: 39-107aa. tag-Free. Homo sapiens (Human). Chemokine Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. It has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. It is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. It can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
Sizen/a
Concentrationn/a
ApplicationsRUO
Other NamesC-X-C Motif Chemokine 2; Growth-Regulated Protein Beta; Gro-Beta; Macrophage Inflammatory Protein 2-Alpha; MIP2-Alpha; CXCL2; GRO2; GROB; MIP2A; SCYB2
Gene, Accession, CAS #CXCL2, UniProt: P19875
Catalog #RPC26800
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Order / More InfoRecombinant Human Interleukin-1 alpha protein (IL1A) (Active) from BIOMATIK
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