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| Product Name | Recombinant Human Interleukin-17A protein (IL17A) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE. MW: 128.4kDa. Extracellular Domain: 25-932aa. C-terminal FC-tagged. Homo sapiens (Human). Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular a chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the a and β chains. The sema domain, which is formed by both a and β chains of HGF R, mediates both ligand binding and receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET |
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| Gene, Accession, CAS # | MET, UniProt: P08581 |
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| Catalog # | RPC26815 |
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| Order / More Info | Recombinant Human Interleukin-17A protein (IL17A) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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