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| Product Name | Recombinant Human Interleukin-36 gamma (IL36G) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 45.7kDa. Full Length: 1-169aa. N-terminal GST-tagged. Homo sapiens (Human). Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | IL-1-related protein 2 |
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| Gene, Accession, CAS # | IL36G, UniProt: Q9NZH8 |
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| Catalog # | RPC23623 |
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| Order / More Info | Recombinant Human Interleukin-36 gamma (IL36G) from BIOMATIK |
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| Product Specific References | n/a |
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