| 产品详情 |
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| Antigenic Specificity | RANK |
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| Clone | 9A725 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1, kappa |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 2-4 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:500, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RANK Monoclonal Antibody (9A725). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. RANK, or Receptor activator of NF-kB, TNF11aR, ODFR, CD265, is a member of the TNFR superfamily with no significant homology to other members of this family . RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival . The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6 . Overexpression of RANK activates NF-kB and c-Jun-term |
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| Immunogen | n/a |
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| Other Names | FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, TNFRSF11A |
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| Gene, Accession # | Entrez: 21934, 498206, 8792; Uniprot: O35305, Q9Y6Q6 |
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| Catalog # | MA5-16153 |
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| Price | |
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| Order / More Info | RANK Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 22531921, 26329493 |
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