| 产品详情 |
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| Antigenic Specificity | Pellino 1 |
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| Clone | OTI10D1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Pellino 1 Monoclonal Antibody (OTI10D1). The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitinatio |
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| Immunogen | n/a |
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| Other Names | E3 ubiquitin-protein ligase pellino homolog 1, pellino-1, pellino-related intracellular-signaling molecule, protein pellino homolog 1 |
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| Gene, Accession # | Entrez: 57162; Uniprot: Q96FA3 |
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| Catalog # | MA5-26914 |
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| Price | |
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| Order / More Info | Pellino 1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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