产品名称 TAB3 Antibody from INVITROGEN ANTIBODIES
产品货号 A302-207A
产品价格 现货询价,电话:010-67529703
产品规格 100 µL
产品品牌 INVITROGEN ANTIBODIES
产品概述
产品详情
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Antigenic SpecificityTAB3
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
Formatpurified
Size100 µL
Concentrationn/a
ApplicationsImmunoprecipitation: 2-10 µg/mg lysate, Western Blot: 1:2,000-1:10,000
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DescriptionTAB3 Polyclonal Antibody. TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and
Immunogenn/a
Other NamesTAB3
Gene, Accession #Entrez: 257397, 66724; Uniprot: Q571K4, Q8N5C8
Catalog #A302-207A
Price
Order / More InfoTAB3 Antibody from INVITROGEN ANTIBODIES
Product Specific Referencesn/a
产品资料