| 产品详情 |
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| Antigenic Specificity | SIAH2 |
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| Clone | 24E6H3 |
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| Host Species | Mouse |
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| Reactive Species | human, porcine |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 500 µl |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:10, Immunocytochemistry: 1:10, Immunofluorescence: 1:10, Immunohistochemistry (Frozen): 1:40-1:50, Immunohistochemistry (Paraffin): 1:40-1:50, Immunohistochemistry: 1:40-1:50, Western Blot: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIAH2 Monoclonal Antibody (24E6H3). SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates. SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent. SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia. It targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription |
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| Immunogen | n/a |
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| Other Names | E3 ubiquitin-protein ligase SIAH2, EC 6.3.2, EC 6.3.2.-, hSiah2, seven in absentia (Drosophila) homolog 2, Seven in absentia homolog 2, seven in absentia homolog 2 (Drosophila), siah-2 |
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| Gene, Accession # | Entrez: 100622531, 6478; Uniprot: O43255 |
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| Catalog # | MA5-24780 |
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| Price | |
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| Order / More Info | SIAH2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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