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| Antigenic Specificity | ALS2CR2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ALS2CR2 Polyclonal Antibody. ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2. |
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| Immunogen | n/a |
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| Other Names | Serine/threonine-protein kinase ALS2CR2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; ILP-interacting protein; CALS-21; ALS2CR2; ILPIP; |
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| Gene, Accession # | Entrez: 55437; Uniprot: Q9C0K7 |
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| Catalog # | PA5-13899 |
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| Price | |
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| Order / More Info | ALS2CR2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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