| 产品详情 |
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| Antigenic Specificity | CD254 (RANK Ligand) |
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| Clone | 12A380 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: Assay dependent, Western Blot: 2-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD254 (RANK Ligand) Monoclonal Antibody (12A380). sRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis |
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| Immunogen | n/a |
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| Other Names | RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCE |
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| Gene, Accession # | Entrez: 21943, 8600; Uniprot: O14788, O35235 |
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| Catalog # | MA1-20347 |
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| Price | |
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| Order / More Info | CD254 (RANK Ligand) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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