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| Product Name | Recombinant Mouse Sonic Hedgehog (Shh) (Cys25/(Ile-Ile)-Gly198) (carrier-free) |
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| Description | Mouse Sonic Hedgehog (Shh) encodes a 437 amino acid precursor protein. It undergoes autocatalytic internal cleavage to yield a non-glycosylated 19 kD N-terminal fragment, which has signaling activity, and a glycosylated 25 kD C-terminal protein that is active in precursor processing. The Shh N-terminal fragment is highly conserved in species such as human, mouse, and rat with a greater 98% amino acids identity. Lipid modification of Shh N-terminal fragment enhances its binding affinity and modulates interactions with the Patched and Smoothened transmembrane receptors. SHH activity is attenuated by its interaction with membrane-associated Hip. On the other hand, interaction with glycans can lead to the stimulation of Shh signaling. Shh is expressed in embryonic tissues that are critical for the patterning of early embryo. It functions as the key inductive signal in the patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Shh regulates the differentiation and proliferation of early thymocyte progenitors as well as neural and hematopoietic stem cell fate. In adult tissues, Shh is associated with cancer development and tissue remodeling following an injury. Gastric Shh acts as a macrophage chemoattractant during an immune response to Helicobacter pylori. It has been shown cystein 24 replacement with two isoleucine residues confered increased activity of human Shh. Similarly, cystein 25's replacement with two isoleucines in mouse Shh resulted in increased activity of the Shh protein. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | TPT, HHG1, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5 |
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| Gene, Accession, CAS # | Gene ID: 20423 |
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| Catalog # | 754602 |
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| Order / More Info | Recombinant Mouse Sonic Hedgehog (Shh) (Cys25/(Ile-Ile)-Gly198) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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