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Product Name | PF-562271 besylate |
Description | F-562271 is an ATP-competitive, reversible inhibitor of FAK (IC50 = 1.5 nM). It displays 10-fold reduced potency for PYK2 (IC50 = 14 nM) and >100-fold selectivity against other protein kinases. PF-562271 inhibits FAK phosphorylation with an EC50 value of 93 ng/ml in glioblastoma-bearing mice and has been shown to regress tumors in multiple xenograft models. MW: 665.66. Purity ≥98% by HPLC |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide, monobenzenesulfonate |
Gene, Accession, CAS # | CAS: 939791-38-5 |
Catalog # | B1253-25 |
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Order / More Info | PF-562271 besylate from BIOVISION, INC. |
Product Specific References | n/a |
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