| 产品详情 |
| Edit |   |
|---|
| Product Name | ITF 2357 |
|---|
| Description | Inhibits maize HDACs: HD2, HD-1B, and HD-1A (IC50s = 7.5-16 nM) and reduces TNFα, IL-1α, and IL-1β production (IC50s = 10-22 nM); inhibits activity of cells expressing JAK2V617F (IC50s = 1-10 nM), which are implicated in the pathophysiology of many myeloproliferative diseases |
|---|
| Size | 5 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 497833-27-9 givinostat histones deacetylases HDACs inhibitors inhibits inhibition pro-inflammatory cytokines janus kinases 2 JAK2 myeloproliferative diseases antitumor antiinflammatory anti-inflammatory anti inflammatory proinflammatory pro inflammatory HD2 HD-1B HD1A HD1B HD1A HD 1B HD 1A TNFα IL-1α IL-1β cytokines tumors necrosis factors interleukins cells JAK2V617F enzymes polycythaemia vera ITF-2357 ITF2357 |
|---|
| Gene, Accession, CAS # | CAS: 732302-99-7 |
|---|
| Catalog # | 11045-5 |
|---|
| Price | |
|---|
| Order / More Info | ITF 2357 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|