| 产品详情 |
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| Product Name | G007-LK |
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| Description | A TNKS1/2 inhibitor (IC50s = 46 and 25 nM, respectively); selective for TNKS1 and TNKS2 over a panel of 90 kinases, 16 phosphatases, and 73 GPCRs; inhibits colony formation of COLO 320 DM and SW403 cells (200 µM); inhibits colony formation of HCC cells in a dose-dependent manner; increases differentiation marker expression in COLO 320 DM and HCT15 cells (100 nM); inhibits Wnt signaling in HEK293 and 10T1/2 cells in a dose-dependent manner; inhibits tumor growth in COLO 320 DM and SW403 mouse xenograft models (20 mg/kg, i.p., twice daily) but leads to moribundity and death at a dose of 30 mg/kg twice daily |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Tankyrase 1/2 Inhibitor VI |
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| Gene, Accession, CAS # | CAS: 1380672-07-0 |
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| Catalog # | 22934-25 |
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| Price | |
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| Order / More Info | G007-LK from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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