| 产品详情 |
| Edit |   |
|---|
| Product Name | Vortioxetine (hydrobromide) |
|---|
| Description | A multimodal serotonergic agent; inhibits 5-HT reuptake (Ki = 1.6 nM); binds to the 5-HT1A, 5-HT1B, 5-HT3A, and 5-HT7 receptors (Kis = 15, 33, 3.7, and 19 nM, respectively); binds to the β1-adrenergic receptor (Ki = 46 nM); acts as an antagonist at 5-HT3A and 5-HT7, a partial agonist at 5-HT1B, and a full agonist at 5-HT1A receptors; selective for SERT over the dopamine and norepinephrine transporters (IC50s = 5.3, 890, and 140 nM, respectively); increases 5-HT levels in vivo in rat brain and decreases occupancy at SERT when administered at a dose of 5 or 10 mg/kg per day; has antidepressant-like and anxiolytic-like effects in mice at 5 mg/kg but not 10 mg/kg |
|---|
| Size | 5 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 508233-74-7 Lu AA21004 LuAA21004 Lu-AA-21004 LuAA-21004 5HT 5HT1A 5HT-1A 5HT1B 5HT-1B 5HT3A 5HT3A 5HT7 5HT-7 b1 b-1 H-2 b2 b-2 5HT2C 5HT-2C 5HT6 5HT-6 5-HT-1A 5-HT-1B 5-HT-3A 5-HT-7 5-HT-2C 5-HT-6 anti-depressant Brintellix Trintellix GPCR SSRI |
|---|
| Gene, Accession, CAS # | CAS: 960203-27-4 |
|---|
| Catalog # | 23694-5 |
|---|
| Price | |
|---|
| Order / More Info | Vortioxetine (hydrobromide) from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|