| 产品详情 |
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| Product Name | ML-240 |
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| Description | ML-240 is an ATP-competitive inhibitor of the D2 domain of the p97 ATPase (IC50 = 110 nM). It disrupts the endoplasmic reticulum-associated degradation and autophagy pathways, preventing the degradation of p97-dependent proteasome substrates (IC50 = 0.9 µM) and causing accumulation of ubiquitin conjugates in nuclear membrane and cytosolic compartments at 5-10 µM. ML-240 has also been shown to block proliferation of HCT15 and SW403 colon cancer cell lines (GI50s = 0.76 and 0.5 µM, respectively) and to rapidly mobilize caspase-3 and -7, inducing apoptosis. MW: 396.44. Purity ≥98% by HPLC |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine |
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| Gene, Accession, CAS # | CAS: 1346527-98-7 |
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| Catalog # | B1142-5 |
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| Order / More Info | ML-240 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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