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| Product Name | Recombinant Mouse G-CSF (carrier-free) |
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| Description | G-CSF is the key hematopoietic cytokine involved in the control of neutrophil production; therefore it is a critical regulator of innate immunity against bacterial infections. G-CSF mobilizes stem cells indirectly by down-regulating the expression of CXCL12 on marrow osteoblasts and by releasing neutrophil and monocyte proteolytic enzymes, including neutrophil elastase, cathepsin G, and matrix metalloproteinase-9, which in turn degrade important HSC-trafficking and adhesion molecules c-kit, VCAM-1, and CXCR4. In addition, G-CSF possesses immunosuppressive effects on monocytes/ macrophages, dendritic cells, and T lymphocytes. The receptor for G-CSF is expressed not only in hematopoietic cells; in addition, it is expressed in cardiomyocytes, skeletal muscle, and neurons. G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. In vitro, G-CSF displays strong antiapoptotic activity in neuronal cells. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | CSF3, CSFG, MGI-IG, Granulocyte colony stimulating factor |
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| Gene, Accession, CAS # | Gene ID: 12985 |
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| Catalog # | 574606 |
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| Order / More Info | Recombinant Mouse G-CSF (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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