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| Product Name | JTE-013 |
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| Description | JTE-013 is a potent, selective S1P2 receptor antagonist that binds to the human and rat receptors with IC50 values of 17 and 22 nM, respectively, (IC50 values >10 µM for human S1P1 and S1P3).{14560} It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells.{14560,14559} JTE-013 inhibits S1P-induced contraction of, as well as cAMP accumulation in, coronary artery smooth muscle cells.{14558,14556} |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | reverses inhibition inhibits coronary artery smooth muscles lipids cells proliferation cytoskeletal morphogenesis GPCRs protein-coupled receptors antagonists S1P2 humans rats EDG5 sphingosines sphingosine-1-phosphates sphingosine1 inhibitors JTE013 FDG-5 cancers |
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| Gene, Accession, CAS # | CAS: 383150-41-2 |
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| Catalog # | 10009458-10 |
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| Order / More Info | JTE-013 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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