| 产品详情 |
| Edit |   |
|---|
| Product Name | JTE-013 |
|---|
| Description | JTE-013 is a potent, selective S1P2 receptor antagonist that binds to the human and rat receptors with IC50 values of 17 and 22 nM, respectively, (IC50 values >10 µM for human S1P1 and S1P3).{14560} It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells.{14560,14559} JTE-013 inhibits S1P-induced contraction of, as well as cAMP accumulation in, coronary artery smooth muscle cells.{14558,14556} |
|---|
| Size | 5 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | reverses inhibition inhibits coronary artery smooth muscles lipids cells proliferation cytoskeletal morphogenesis GPCRs protein-coupled receptors antagonists S1P2 humans rats EDG5 sphingosines sphingosine-1-phosphates sphingosine1 inhibitors JTE013 FDG-5 cancers |
|---|
| Gene, Accession, CAS # | CAS: 383150-41-2 |
|---|
| Catalog # | 10009458-5 |
|---|
| Price | |
|---|
| Order / More Info | JTE-013 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|