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| Product Name | Recombinant Rat SCF (carrier-free) |
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| Description | Rat stem cell factor (SCF) was identified and purified from the culture medium conditioned by buffalo rat liver cells. It is synthesized as membrane-bound forms of 273 amino acids. The protein contains a proteolytic cleavage site that is cleaved from the cell to release an active soluble protein. The soluble SCF is glycosylated at both N-linked and O-linked sites. MMP-9 plays a physiological role in SCF release from the membrane, and this action has a significant part to play in differentiating and mobilizing stem and progenitors cells from the bone marrow. SCF increases the proliferation of myeloid and lymphoid hematopoietic progenitors in bone marrow cultures. SCF/c-kit interaction in mast cells results in mast cell degranulation and liberation of mediators, such as histamine, inflammatory cytokines, and chemokines. Also, activation of c-kit in dendritic cells regulates T helper cell differentiation and allergic asthma. In addition, SCF plays an important role in revascularization of ischemic limbs. Ischemia induces plasma elevation of SCF and thrombopoietin (TPO) and lower levels GM-CSF and erythropoietin (EPO). SCF and TPO induces the release of CXCL12 from platelets thereby increasing CXCL12 levels in plasma, which results in an extensive mobilization of CXCR4+VEGFR1+ cells (hemangiocytes) that accelerate the revascularization of ischemic limbs. SCF and its receptor (c-kit) drive the recruitment and expansion of different stem cell types such as hematopoietic, neuronal, germ, and cardiac. SCF gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Also, c-Kit signaling plays a key role in the pancreas, including islet morphogenesis, islet vascularization, and beta cell survival and function. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | KIT-ligand, Kitl, KL-1, mast cell grow factor (MGF), steel factor (SF), FPH2, SHEP7 |
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| Gene, Accession, CAS # | Gene ID: 60427 |
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| Catalog # | 752008 |
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| Order / More Info | Recombinant Rat SCF (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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