| 产品详情 |
| Edit |   |
|---|
| Product Name | PF-04447943 |
|---|
| Description | A brain-permeable PDE inhibitor selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM); over 1,000-fold more selective for PDE9A over 79 non-PDE targets, with the exception of the melatonin MT3/ML2 receptor (Ki = 3,800 nM); inhibits rat and rhesus monkey PDE9A (Kis = 18.1 and 4.5 nM, respectively); increases neurite outgrowth and the density of synapsin puncta in primary rat hippocampal neurons (0.03 µM); improves scopolamine-induced deficits in episodic memory in rats and increases the time spent exploring the novel object in the NOR test (1 mg/kg); improves spatial memory in the MWM and decreases the distance traveled to the hidden platform (3.2 mg/kg) |
|---|
| Size | 10 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 1421852-72-3 PF4447943 PF04447943 PDE-9A MT-3 ML-2 |
|---|
| Gene, Accession, CAS # | CAS: 1082744-20-4 |
|---|
| Catalog # | 24299-10 |
|---|
| Price | |
|---|
| Order / More Info | PF-04447943 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|