| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Rat E-Cadherin-Fc Chimera (carrier-free) |
|---|
| Description | E-cadherin, also known as cadherin-1, CDH1 and CD324, is a member of the cadherin superfamily. E-cadherin is widely expressed in epithelial cells. It is a calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of four extracellular cadherin repeats and a highly conserved cytoplasmic tail region. E-cadherin functions as a cell adhesion molecule involved in development, bacterial pathogenesis, and tumor invasion. E-cadherin forms homophilic clusters via cis and trans interactions to stabilize the catenin and actin cytoskeleton in epithelial adherens junctions. E-cadherin and α-catenin can form distinct complexes with β-catenin and plakoglobin, respectively. Mice lacking E-cadherin in the epidermis leads to perinatal death and loss of barrier function. Regulating E-cadherin turnover is essential to modulate epithelial plasticity during tissue remodeling and stretching. In bacterial pathogenesis, the ectodomain of E-cadherin mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization. E-cadherin binds to the αEβ7 integrin to mediate cell adhesion. It also interacts with a number of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II as well as other extracellular proteins including the EGF receptor. E-cadherin is phosphorylated on multiple residues (S857, S866, S870, S872), and can be proteolytically cleaved at residue D769 by caspase-3. There are several diseases associated with dysregulation of E-cadherin, including Hailey-Hailey disease and Blepharocheilodontic syndrome 1 (BCDS1). |
|---|
| Size | 10 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | E-cadherin, Cadherin-1, CAD1, CDH1, CADH1, ARC-1, CD324, CAM 120/80, Epithelial cadherin, Uvomorulin, CDHE, UVO |
|---|
| Gene, Accession, CAS # | Gene ID: 83502 |
|---|
| Catalog # | 780102 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Rat E-Cadherin-Fc Chimera (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|