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| Product Name | Recombinant Rat E-Cadherin-Fc Chimera (carrier-free) |
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| Description | E-cadherin, also known as cadherin-1, CDH1 and CD324, is a member of the cadherin superfamily. E-cadherin is widely expressed in epithelial cells. It is a calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of four extracellular cadherin repeats and a highly conserved cytoplasmic tail region. E-cadherin functions as a cell adhesion molecule involved in development, bacterial pathogenesis, and tumor invasion. E-cadherin forms homophilic clusters via cis and trans interactions to stabilize the catenin and actin cytoskeleton in epithelial adherens junctions. E-cadherin and α-catenin can form distinct complexes with β-catenin and plakoglobin, respectively. Mice lacking E-cadherin in the epidermis leads to perinatal death and loss of barrier function. Regulating E-cadherin turnover is essential to modulate epithelial plasticity during tissue remodeling and stretching. In bacterial pathogenesis, the ectodomain of E-cadherin mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization. E-cadherin binds to the αEβ7 integrin to mediate cell adhesion. It also interacts with a number of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II as well as other extracellular proteins including the EGF receptor. E-cadherin is phosphorylated on multiple residues (S857, S866, S870, S872), and can be proteolytically cleaved at residue D769 by caspase-3. There are several diseases associated with dysregulation of E-cadherin, including Hailey-Hailey disease and Blepharocheilodontic syndrome 1 (BCDS1). |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | E-cadherin, Cadherin-1, CAD1, CDH1, CADH1, ARC-1, CD324, CAM 120/80, Epithelial cadherin, Uvomorulin, CDHE, UVO |
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| Gene, Accession, CAS # | Gene ID: 83502 |
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| Catalog # | 780106 |
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| Order / More Info | Recombinant Rat E-Cadherin-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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