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| Product Name | A-77636 (hydrochloride) |
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| Description | An agonist of the dopamine D1 receptor (Ki=40 nM); induces activity equal to or greater than dopamine in fish retinas and rat caudate-putman (EC50s = 7.4 and 1.1 nM, respectively); does not show agonist behavior for the D2 receptor expressed in MMQ cells (≤10 µM); induces desensitization of dopamine-stimulated cAMP accumulation and reduces D1 receptor expression by 79% in C-6 glioma cells expressing monkey D1A receptors (10 µM); increases locomotor activity 5.3-fold and reduces disease severity in a MPTP-treated marmoset model of Parkinson's disease (3 µmol/kg s.c.); elicits over a 230% increase in cortical and hippocampal acetylcholine release (4 µmol/kg, s.c.) |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 778546-51-3 A77636 D-1 2 1A C6 SCH23390 |
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| Gene, Accession, CAS # | CAS: 145307-34-2 |
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| Catalog # | 24316-10 |
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| Order / More Info | A-77636 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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