| 产品详情 |
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| Antigenic Specificity | CD45 |
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| Clone | HI30 |
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| Host Species | Mouse |
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| Reactive Species | human, cross-reactivity: chimpanzee |
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| Isotype | IgG1, κ |
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| Format | Brilliant Violet 421™ conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Brilliant Violet 421™ anti-human CD45. CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. |
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| Immunogen | n/a |
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| Other Names | LCA, T200, B220 |
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| Gene, Accession # | Gene ID: 5788 |
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| Catalog # | 304031 |
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| Price | |
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| Order / More Info | CD45 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18544681,21138865,22828869,24648400,25672754,25687281,25687283 |
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