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| Product Name | Recombinant Human CD161/CLEC5B-Fc Chimera (carrier-free) |
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| Description | CLEC5B (CD161, KLRB1, NKR-P1A) is a C-type lectin protein belonging to the natural killer (NK) cell receptor family. Human CLEC5B is a 225 amino acid type II transmembrane glycoprotein. It contains a 158 amino acid extracellular domain with several motifs characteristic of C-type lectins, a 29 amino acid transmembrane domain, and a 38 amino acid cytoplasmic domain. CLEC5B plays an inhibitory role on NK cells by binding to CLEC2D/LLT1 and inhibiting NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. CLEC5B also reportedly acts as a potentiation receptor on T cells to increase IFN-gamma production in concert with TCR engagement. CLEC5B is known to be expressed by a distinct set of lymphocytes, in a subset of NK cells predominantly in intestinal epithelium and liver. It is also detected in peripheral blood T-cells, preferentially in adult T-cells with a memory antigenic phenotype. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | KLRB1, CD161, NKRP1A, NKR, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, NKRP1A, NKR-P1 |
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| Gene, Accession, CAS # | Gene ID: 3820 |
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| Catalog # | 780304 |
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| Order / More Info | Recombinant Human CD161/CLEC5B-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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