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| Product Name | Recombinant Human IL-35-Fc fusion protein (ELISA Std.) |
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| Description | IL-35 is a newly described cytokine comprised of the IL-12α chain (p35) and the Epstein-Barr virus-induced gene product 3 (EBI-3). IL-35 belongs to the IL-12 family which includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimeric proteins comprised of an α chain (p19, p28, or p35) and a β chain (p40 or Ebi3). Mouse IL-35-Fc fusion protein enhances the proliferation of mouse Treg cells, while inhibiting the development of Th17 cells. Human IL-35 can suppress the proliferation of umbilical cord-derived human CD4 T conventional cells, to a similar extent as activated Tregs. In addition, activation of human CD4 T conventional cells with anti-CD3 and anti-CD28 in the presence of IL-35 induces the expression of IL-35 in these cells. Interestingly, activated T conventional cells treated with IL-35 acquire a regulatory phenotype (iTreg35) that suppress via IL-35. Most recent data suggest that IL-35 secreted by ICOS+ Tregs can suppress IL-17 production and reverse established IL-17-dependent allergic airways disease in mice. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | IL-35 subunits: IL-12 subunit alpha (p35), IL-27 subunit beta (EBI3) |
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| Gene, Accession, CAS # | Gene ID: 3592, 10148 |
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| Catalog # | 578502 |
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| Order / More Info | Recombinant Human IL-35-Fc fusion protein (ELISA Std.) from BIOLEGEND |
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| Product Specific References | n/a |
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