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| Product Name | Recombinant Human IL-36γ (Animal-Free) |
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| Description | The IL-1 family is a group of cytokines comprised of 11 membranes, including recently renamed IL-36 cytokines, IL-36α, β and γ (previously known as IL-1F6, IL-1F8 and IL-1F9). IL-36γ signals through the IL-1 receptor family members IL-1Rrp2 and IL-1RAcP and can activate downstream MAP kinases and transfection factor NF-kB. IL-36γ is synthesized without signal peptide and the secretion pathway is unclear. It has been shown that, like other IL-36 cytokines, N-terminal processing of IL-36γ can significantly increase its biological activity. The possible processing enzymes are currently unknown. IL-36γ also plays a significant role in immune response. Low level of IL-36 receptor IL-1Rrp can be detected on bone marrow-derived dendritic cells and CD4+ T cells. IL-36γ treatment can upgulate CD80, CD86 and MHC Class II, and proinflammatory cytokine producton in dendritic cells. IL-36γ has also been implicated in airway hyperesponsiveness. Intranasal administration of recombinant IL-36γ in mice leads to epithelial cell hypertrophy, cellular infiltration, and mucus production. IL-36γ expression in the lungs of mice can be upregulated by allergic inflammation. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | IL-1F, IL-1ε, IL-1H1, IL-36g, IL-36 gamma, IL36, IL1F, IL1H1, IL-1e, IL1epsilon, IL1e |
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| Gene, Accession, CAS # | Gene ID: 56300 |
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| Catalog # | 711602 |
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| Order / More Info | Recombinant Human IL-36γ (Animal-Free) from BIOLEGEND |
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| Product Specific References | n/a |
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