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| Product Name | Recombinant Rat CRP (carrier-free) |
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| Description | C-Reactive Protein (also known as CRP and Pentraxin 1), is a member of pentraxin protein family that are characterized by a cyclic pentameric structure. CRP is a pattern recognition molecule that is able to recognize pathogens and promote their clearance. Human and mouse CRP are non-glycosylated proteins that tends to form a non-covalently linked pentamer with each subunit made up of two antiparallel β-sheets and a single short α-helix. It is characterized by the presence of a cleft that extends from the center of the subunit to its edge at the central pore of the pentamer structure. In contrast, rat CRP is a glycosylated protein that contains a covalently linked dimer in the pentameric structure. CRP exhibits Ca2+ dependent binding to ligands. It has been demonstrated that CRP binds to the phosphocholine moieties expressed on the surface of dead or dying cells and some bacteria. This leads to the activation of the complement system and promotion of phagocytosis by macrophages to clear necrotic and apoptotic cells. Ligand bound CRP also binds to Fc gamma RI and Fc gamma RIIa on phagocytes and activates phagocytotic responses. CRP is secreted by hepatocytes and is a biomarker for inflammation. IL-6 has been shown to be an effective inducer of this protein. Besides binding to apoptotic cells, CRP also binds to a variety of molecules including C1q, bacterial polysaccharide, CD64, CD32, APCS, HDL, and fibronectin. In addition to participating in immune responses, CRP is also a prominent partaker in endothelial dysfunction and atherosclerosis. It was shown that CRP may exhibit direct proantherogenic effects by upregulating angiotensin type I receptor in smooth muscle cells and promoting their migration, proliferation, neointimal formation, and reactive oxygen species production. Mature human CRP shares 71% amino acid sequence homology with its mouse counterpart. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | CRP, Pentraxin1, PTX1, C-reactive protein, pentraxin-related |
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| Gene, Accession, CAS # | Gene ID: 25419 |
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| Catalog # | 763806 |
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| Order / More Info | Recombinant Rat CRP (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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