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| Product Name | Recombinant Human CD30L (TNFSF8) (carrier-free) |
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| Description | CD30L is a type II membrane glycoprotein belonging to the TNFL superfamily that includes CD27L (CD70), FasL (CD95L), CD120a (TNF-R1), CD120b (TNF-R2), OX40L (CD134L), 4-1BB ligand (CD137L), and CD40L (CD154). CD30 is a member of the TNF receptor superfamily, and it was originally identified as a cell surface antigen, Ki-1, on Hodgkin and Reed-Sternberg cells. Recombinant murine CD30L shares functional properties with CD40L in the regulation of murine B cell growth and differentiation in vitro. CD30L stimulated B cell proliferation, antigen-specific antibody production, and polyclonal immunoglobulin secretion in a cytokine-dependent manner; IL-4 and IL-5 are required for B cell proliferation and IL-2 and IL-5 for antigen-specific production. Interaction of CD30L, expressed in human B cells, with CD30+ T cells inhibits class switching and antibody production in human IgD+, IgM+ B cells. Cross-linking of CD30 ligand by a monoclonal antibody or by CD30-Fc fusion protein induced production of IL-8 by freshly isolated neutrophils. The signaling induced from the receptor to the cell expressing the transmembranal ligand has been denominated “reverse signaling.” CD30L/CD30 signaling seems to be involved in Th1 and Th2 cell responses and plays a key role in Th17 differentiation in mice. The CD30/CD30L signaling system has been implicated in the pathogenesis of several autoimmune and inflammatory conditions such as RA. Patients with RA have high levels of soluble CD30L (sCD30L) in sera and synovial fluid, and sCD30L inhibits CD30+ T cell proliferation by inducing cell apoptosis. Mast cells are the predominant CD30L-positive cell in chronic inflammatory skin diseases such as psoriasis and atopic dermatitis, and CD30 and CD30L expression is upregulated in lesional skin in these conditions. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Tumor necrosis factor ligand superfamily member 8 (TNFRSF8), CD153, CD30LG, CD30 antigen ligand, tumor necrosis factor ligand 3A, TNLG3A |
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| Gene, Accession, CAS # | Gene ID: 944 |
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| Catalog # | 767104 |
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| Order / More Info | Recombinant Human CD30L (TNFSF8) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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