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| Product Name | Protein A, Recombinant |
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| Description | Highly Purified (~98%). The common bacterial pathogen, Staphylococcus aureus, produces a 42kD factor, protein A (SpA). The biological role of protein A is not understood fully, although it is secreted by nearly all clinical isolates of S. aureus and is thought to enhance pathogenicity. Protein A interacts with antibodies through two distinct binding events: the ``classical'' binding site on the Fc portion of human IgG1, IgG2, and IgG4, and the ``alternate'' binding site found on the Fab portion of human IgG, IgM, IgA, and IgE that contain heavy chains of the VH3 subfamily. Protein A has long been studied for its properties as a valuable immunological tool and more recently for its ability to act as a B cell superantigen by cross-linking IgM molecules through VH3- mediated binding. Protein A contains five homologous;58 residue immunoglobulin (Ig)-binding domains followed by a C-terminal region necessary for cell wall attachment. The Ig binding domains are designated E, D, A, B, and C ~in or |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209155 |
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| Order / More Info | Protein A, Recombinant from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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