| 产品详情 |
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| Antigenic Specificity | CD8a |
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| Clone | RPA-T8 |
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| Host Species | Mouse |
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| Reactive Species | human, cross-reactivity: chimpanzee, baboon, cynomolgus, rhesus, pigtailed macaque, sooty mangabey |
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| Isotype | IgG1, κ |
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| Format | Brilliant Violet 650™ conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Brilliant Violet 650™ anti-human CD8a. CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation, and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck. |
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| Immunogen | n/a |
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| Other Names | T8, Leu2 |
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| Gene, Accession # | Gene ID: 925 |
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| Catalog # | 301041 |
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| Price | |
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| Order / More Info | CD8a Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18490743,19849846 |
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| 产品资料 |
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