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| Product Name | Recombinant Human FAS (TNFRSF6)-Fc Chimera (carrier-free) |
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| Description | FAS was initially purified and cloned from SKW6.4 cells and a cDNA library of human T cell lymphoma KT-3 cells. FAS is a type I transmembrane protein and belongs to the TNF receptor superfamily. The extracellular region of FAS possesses three cystein-rich domains characteristic of the TNF superfamily, and the intracellular region which includes a death domain (DD). The binding of FASL to FAS induces conformational changes in FAS, leading to the recruitment of FADD and procaspase-8 and the assembly of the death-inducing signaling complex (DISC). Subsequently, caspase 8 is released from DISC and induces activation of caspase 3 and 7, proteolysis of cellular components, and apoptosis. Other biological effects not leading to apoptotic cell death have also been described. The interaction of FAS/FASL in immature dendritic cells (DCs) induces functional maturation. Fas-activated DCs increase the expression of MHC II, B7 co-stimulatory molecules, and DC-lysosome-associated membrane proteins (DC-LAMP), and secrete proinflammatory cytokines such as IL-1β and TNF-α. In addition, FAS/FASL interaction increases the production of chemokines in NK-T cells, and FASL acts as a survival factor for human CD34+ cells and increases their colony formation. Human activated PBMC and tumor cell lines express full-length mRNA and several mRNA FAS variants derived by alternative splicing; deletion of an exon encoding the transmembrane domain results in a soluble FAS molecule that blocks apoptosis. Patients with systemic lupus erythematosus show high levels of sFAS. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), ALPS1A, APO-1, APO1, Apoptosis antigen 1 (APT1), CD95, FAS1, FASTM, FS-7-associated surface antigen |
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| Gene, Accession, CAS # | Gene ID: 355 |
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| Catalog # | 555008 |
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| Order / More Info | Recombinant Human FAS (TNFRSF6)-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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