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| Product Name | Recombinant Mouse IL-5Rα-Fc Chimera (carrier-free) |
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| Description | The IL-5 receptor is a heterodimer including a ligand-specific IL-5Rα and a β subunit (CSF2RB, also called common β subunit, βc), shared with IL-3 and GM-CSF. IL-5Rα, also known as CD125, belongs to the type I cytokine receptor family, which contains a conserved WSXWS motif in the extracellular domain and a box 1 motif in the cytoplasmic tail. In human, there are several isoforms present due to alternative splicing, including membrane-bound isoforms and soluble isoforms. Membrane-bound IL-5Rα initially binds to IL-5 and then recruits βc, which is required for preventing the complex from dissociating and triggering the downstream signaling transduction. Juxtamembraneous kinases, including Lyn and JAK are essential for IL-5R phosphorylation, leading to the recruitment and the activation of STAT family. Unlike membrane-bound isoform, soluble isoform is considered as an antagonist. IL-5Rα is mainly expressed on eosinophils, basophils and B cells, and it is known to regulate the differentiation and function of eosinophils, basophils and B cells in human and mice. Soluble IL-5Rα inhibits antigen-induced hyper-eosinophilia. IL-5Rα is required for IL-5-induced cell proliferation and immunoglobulin production during B cell development. It has reported that IL-5 can upregulate the expression of membrane form in murine myeloid cell line and human CD34+ progenitor cells. In contrast, membrane-bound IL-5Rα is downregulated in mature eosinophils upon IL-5, IL-3 or GM-CSF treatment. In mice, IL-5Rα is also detected in astrocytes and the expression of isoforms is highly regulated during brain development, but no expression in adulthood. However, the isoforms are produced upon inflammation in mice, indicating IL-5/IL-5Rα serves as an autocrine/paracrine function in mouse brain. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin-5 receptor subunit alpha (IL-5Rα), IL-5R alpha, IL-5R subunit alpha, CD125, IL-5Ra, IL-5RA |
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| Gene, Accession, CAS # | Gene ID: 16192 |
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| Catalog # | 765004 |
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| Order / More Info | Recombinant Mouse IL-5Rα-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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