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| Product Name | Recombinant Human BMP-4 (carrier-free) |
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| Description | Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. BMPs play a key role in embryonic development, especially during heart, neural and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, composed of type I and II subtypes. Four type I receptors have been identified: type IA and IB BMP receptors, type IA activin receptor, and activin receptor-like kinase I. Three type II receptors have also been recognized: type II BMP receptor and type II / IIB activin receptors. BMP-4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish. BMP-2 and BMP-4 are highly similar; they have 92% amino acid sequence identity. BMP-4 is required for mesoderm formation and patterning in mice, and BMP-4 KO mice are embryonic-lethal. BMP-4 has an important role in postnatal tooth cytodifferentiation. Overexpression BMP-4 has been associated with fibrodysplasia ossificans progressiva (FOP). Overexpression of BMP-4 has also been associated with cancer, including melanoma, hepatocellular carcinoma, adenocarcinoma and colorectal cancer cell lines. This overexpression can promote migratory and invasive properties of cancer cells. |
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| Size | 2 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Bone morphogenetic protein 4 (BMP4), Bone morphogenetic protein 2B (BMP-2B) |
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| Gene, Accession, CAS # | Gene ID: 652 |
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| Catalog # | 595201 |
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| Order / More Info | Recombinant Human BMP-4 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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