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| Product Name | Recombinant Human IL-22RA2 (IL-22BP) Fc Chimera (carrier-free) |
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| Description | IL-22BP is a class 2 cytokine receptor family member (CRF2); it is a soluble receptor that does not have transmembrane and cytosolic domains. IL-22BP binds to IL-22 and does not bind to other members of the IL-10 family. IL-22 signals through the mechanism that involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. IL-22R1 expression is restricted to epithelial cells, hepatocytes, and acinar cells of the pancreas, whereas IL-10Rβ1 expression is ubiquitous. IL-22BP prevents the binding of IL-22 to the membrane bound IL-22R1. IL-22 has high affinity binding for IL-22BP, and it is 20- to 1000-fold higher compared to its binding to the membrane bound IL-22R1. IL-22BP inhibits IL-22 biological effects in vitroand in vivoand is constitutively expressed in secondary lymphoid organs, breast, and epithelial tissues such as gut, lung, and skin.IL-22BP plays a key role in controlling tumorigenesis and epithelial cell proliferation in the colon. High expression of IL-22BP has been detected in gastric adenoma tissues. In addition, non-affected skin of psoriasis patients shows lower expression of IL-22BP than skin of healthy controls; this decrease in IL-22BP exacerbates psoriatic skin inflammation. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin-22 Receptor Subunit Alpha-2, IL-22 receptor-alpha 2, IL-22R-alpha-2, IL-22RA2, Interleukin 22-Binding Protein, 22 Receptor Subunit Alpha-2, IL-22BP, Cytokine Receptor Family 2 Member 10, IL-22 Receptor Subunit Alpha-2 |
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| Gene, Accession, CAS # | Gene ID: 116379 |
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| Catalog # | 766508 |
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| Order / More Info | Recombinant Human IL-22RA2 (IL-22BP) Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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