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| Product Name | Recombinant Human IL-36Ra (IL-1F5) (carrier-free) |
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| Description | IL-36Ra belongs to IL-1 cytokine family, as a receptor antagonist. Like other IL-36 cytokines, IL-36Ra does not contain caspase cleavage sites, but removal of N-terminal methionine is required for its full activity, which might be mediated by neutrophil elastase. IL-36Ra shares sequence homology with IL-1Ra, another receptor antagonist of the IL-1 family. IL-36Ra inhibits IL-36α, IL-36β, IL-36γ signaling by preventing their binding to IL-1RL2/IL-36R and the recruitment of IL-1RAP co-receptor, leading to blockage of downstream NF-kB and MAP kinase activation. The mechanism of inhibition is similar to the one that is established between IL-1Ra and IL-1. IL-36Ra is involved in innate immunity and anti-inflammatory responses. IL-36Ra attenuates IL-36 cytokine-induced pro-inflammatory cytokine production by bone marrow derived dendritic cells and antagonizes IL-36 cytokine-induced IFN-γ, IL-4, and IL-17 production in CD4+ T cells. In addition, the anti-inflammatory effect of IL-36Ra in brain is SIGIRR/TIR8-dependent. The deficiency of IL-36Ra is linked to psoriasis in humans. The deficit of IL-36Ra exacerbates skin inflammation in IL-36α transgenic mice, suggesting the importance of IL-36Ra as anti-inflammatory cytokine. The expression of IL-36Ra is induced by PMA and LPS in THP-1 cells and by Aspergillus fumigatus in human PBMCs. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | IL-36 receptor antagonist protein, IL-36RN, IL-1F5, IL-1HY1, IL-1 delta, IL-1L1, FIL1 delta |
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| Gene, Accession, CAS # | Gene ID: 26525 |
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| Catalog # | 760908 |
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| Order / More Info | Recombinant Human IL-36Ra (IL-1F5) (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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