| 产品详情 |
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| Product Name | MLKL Inhibitor, Necrosulfonamide |
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| Description | Purity ~95% (HPLC). A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124nM and 2uM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. Primary Target: human MLKL Molar Mass: 461.5 Solubility: DMSO |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MLKL Inhibitor, Necrosulfonamide ((E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217559 |
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| Order / More Info | MLKL Inhibitor, Necrosulfonamide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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