| 产品详情 |
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| Product Name | Recombinant Human IL-3 (Animal-Free) |
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| Description | Interleukin-3 is a hematopoietic growth factor involved in the survival, proliferation, and differentiation of multipotent hemopoietic cells. IL-3 is the most potent growth factor for basophils, followed by granulocyte-macrophage colony-stimulating factor and IL-5. These cytokines also act on mature basophils through specific receptors, thereby mediating adhesion, migration, and releasability. IL-3 is highly expressed by mast cells, and large and rapidly released amounts of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. IL-3 has also been implicated in the pathogenesis of several chronic inflammatory diseases, including asthma, atherosclerosis, and neurodegenerative disorders, such as multiple sclerosis. IL-3 stimulates colony formation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. IL-3 plays a vital role in stimulating basophils and mast cell responses to parasite infections, and since basophils play an important role in Th2 immune responses, IL-3 is a critical regulator of allergic inflammation. IL-3 is expressed in the major embryonic vessels and regulates the survival and proliferation of hematopoietic stem cells in the early stages of embryonic development. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin-3, Burst promoting activity (BP/BPA), Eosinophil colony stimulating factor (Eo-CSF), Hematopoietic cell growth factor (HCGF), Mast cell growth factor (MGF/MCGF), Multi-colony stimulating factor (multi-CSF), P cell stimulating activity (PCSA) |
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| Gene, Accession, CAS # | Gene ID: 3562 |
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| Catalog # | 714702 |
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| Order / More Info | Recombinant Human IL-3 (Animal-Free) from BIOLEGEND |
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| Product Specific References | n/a |
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