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| Product Name | Recombinant Mouse Galectin-4 (carrier-free) |
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| Description | Galectins constitute a family of conserved animal lectins, which are characterized by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition domain (CRD). In vertebrates, the Galectin family consists of 15 members. Galectins have been classified into three types: 1) Prototype monomeric galectins with a single polypeptide chain that dimerize (Galectin-1, -2, -5, -7, -10, -11, -13 -14, and -15), 2) Tandem repeat galectins composed of a single polypeptide chain with two CRDs, which are joined by a linker peptide (Galectin-4, -6, -8, -9, and -12), and c) Chimeric galectin, which thus far contains only Galectin-3 and consists of one C-terminal CRD linked to a N-terminal domain. Galectin-4 was initially identified in the gastrointestinal mucosa. RNAse protection assays revealed that is not expressed in brain, kidney, skeletal muscle, heart, liver, and lung tissues. Similar to other galectins, Galectin-4 does not have a signal peptide and is synthesized as a cytosolic protein, but it can be secreted. Galectin-4 controls intestinal inflammation and it binds to activated T cells at the CD3 region, which results in a potent inhibition of the cell cycle progression and the induction of antigen-induced cell death. Galectin-4 induces T cell death through the caspase-independent calcium-calpain signaling pathway. Galectin-4 is downregulated in colon cancer tissues and is absent in invasive carcinomas. Nevertheless, high levels in serum are detected in patients with colon and breast cancers. In contrast, it is considerably upregulated in pancreatic adenocarcinomas, hepatocellular carcinomas, and gastric cancers. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Lectin, galactoside-binding, soluble, 4 (LGALS4), GAL4, L36LBP |
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| Gene, Accession, CAS # | Gene ID: 16855 |
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| Catalog # | 755104 |
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| Order / More Info | Recombinant Mouse Galectin-4 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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