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| Product Name | Human CellExp™ ICOSLG /B7-H2 /CD275, Fc Tag, Human Recombinant |
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| Description | AA Asp 19 - Ser 258. Purity >95% as determined by SDS-PAGE. This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.1 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand |
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| Gene, Accession, CAS # | ICOSLG, Gene ID: 23308, Accession: O75144 |
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| Catalog # | P1384-50 |
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| Order / More Info | Human CellExp™ ICOSLG /B7-H2 /CD275, Fc Tag, Human Recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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