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| Product Name | Recombinant Human Neuropilin-1 (carrier-free) |
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| Description | Neuropilin-1 (NRP1) is a type I transmembrane receptor that functions to mediate angiogenesis and neurogenesis, binding members of the vascular endothelial growth factor (VEGF) family and class III semaphorins (Sema III). Due to lack of catalytic activity of its cytoplasmic domain, NRP1 is considered to exert signaling functions via recruitment of or complex formation with other receptors, including plexins for the downstream effects of semaphorins on growth-cone collapse and axonal guidance via recruitment of monomeric GTPases of the Rho family, and VEGF receptor 2 (VEGFR2) for the VEGF-induced endothelial cell proliferation, migration, and vascular remodeling via PI3K/Akt signal transduction pathway. Highly expressed in endothelial cells with KDR/FLK-1 (VEGFR2), NRP1 promotes the anchoring of 165–amino acid isoform of vascular endothelial growth factor A (VEGF-A165) with KDR as well as VEGF165-regulated chemotaxis, playing central roles in embryonic and neural vascularization as well as tumor development and progression, especially in breast, lung, prostate, pancreatic and colon carcinomas. Alternative splicing produces several isoforms whose size ranges from 551 to 704 amino acid residues, though only two soluble ones—namely, s12NRP1 (NRP1 isoform b) and sIVNRP1 (NRP1 isoform c)—are known to exist in protein form and found in protein databases. While NRP gene knockout is strongly implicated in broad categories of neuronal and cardiovascular dysfunctions, its overexpression predicates embryonic lethality by inducing capillary overgrowth, hemorrhage in the head, neck and heart, as well as uncontrolled sprouting and nerve fiber defasciculation. Also facilitating T-cell maturation and activation in the immune system, NRP1 and plexin A1 are upregulated in response to IFNγ activation of microglia exerting neuroprotective effects against potential damage by triggering microglial apoptosis through Sema3A. NRP1’s role in wound healing has also been identified in mouse models with cerebral ischemia, the mRNA expression of NRP1 elevated in response to the injury and remaining so for at least a month. With its localization to ischemic neurons and brain vessel endothelial cells, NRP1 mediates both neuronal growth and angiogenesis. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | NRP1, NRP-1, NPN1, NP1, NRP, VEGF165R, Vascular endothelial growth factor-165 receptor, BDCA4, Blood Dendritic cell antigen 4 |
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| Gene, Accession, CAS # | Gene ID: 8829 |
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| Catalog # | 768004 |
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| Order / More Info | Recombinant Human Neuropilin-1 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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