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| Product Name | Recombinant Human TNFRSF10D (TRAIL R4)-Fc Chimera (carrier-free) |
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| Description | TNFRSF10D, also called TRAIL R4 and DcR2, is a member of the TNF receptor superfamily. It contains a cysteine-rich extracellular domain, a transmembrane domain and an intracellular truncated death domain, which is capable of inducing apoptosis. Its extracellular domain shows 60 % and 56% identity to the extracellular domain of human TNFRSF10A (TRAIL R1) and TNFRSF10B (TRAIL R2), respectively. TNFRSF10D, as one of decoy receptors, protects cells from TRAIL-induced apoptosis via competitive ligand binding with TNFRSF10A and TNFRSF10B. Some evidences indicated that TNFRSF10D blocks apoptosis via the association with TNFRSF10B. Its expression is widely expressed in several tissues but restricted to normal cells. It is considered as a reason for TRAIL sensitivity in tumors. The expression of TNFRSF10D is up-regulated upon p53 overexpression. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), TRAIL receptor 4, Decoy receptor 2 (DcR2), CD264, TRAIL receptor with a truncated death domain (TRUNDD), APO-2L |
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| Gene, Accession, CAS # | Gene ID: 8793 |
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| Catalog # | 768406 |
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| Order / More Info | Recombinant Human TNFRSF10D (TRAIL R4)-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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