| 产品详情 |
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| Product Name | AM966 |
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| Description | A potent and selective LPA1 receptor antagonist (IC50 = 17 nM); selective for LPA1 over the LPA2, LPA3, LPA4, and LPA5 receptors (IC50s = 1,700, 1,600, 7,700, and 8,600 nM for LPA2-5, respectively); inhibits LPA-induced lung fibroblast cell chemotaxis (IC50 = 181 nM); reduces inflammation, tissue fibrosis, and vascular permeability in mice at a dose of 30 mg/kg following bleomycin-induced lung injury; blocks amitriptyline-induced ERK1/2, CREB, and IGF-IR phosphorylation in vitro |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AM-966 LPA-1 2 3 4 5ERK-1 2 IGFIR |
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| Gene, Accession, CAS # | CAS: 1228690-19-4 |
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| Catalog # | 22048-5 |
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| Price | |
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| Order / More Info | AM966 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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